The study focused on elderly patients who were taking multiple medications and therefore were at risk for poor adherence. The educational component included intensive and frequent counseling by a pharmacist. The structural component involved packaging of medications in blister packs that contained each patient's daily medications.After 6 months of the intervention, the percentage of patients classified as adherent increased significantly, from 61.2% at baseline to 96.9%, with associated modest reductions in systolic blood pressure and low-density lipoprotein (LDL) cholesterol. Six months after randomization, high adherence persisted (95.5%) in patients assigned to continuing counseling and the blister packs, whereas those in the usual care group (ie, had the pharmacy care intervention removed) had substantial declines in medication adherence (69.1% at the end of 6 months). There were statistically significant but modest reductions in systolic blood pressure in the pharmacy care group compared with the control group, but no significant differences in LDL cholesterol levels.
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